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If symptoms do occur,the most common ones are blood in the stool, change in bowel habit, lower abdominal pain.Iron deficiency and weight loss may be signs of CRC

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Kandioler D, Zwrtek R, Ludwig C, Janschek E, Ploner M, Hofbauer F, Kuhrer I, Kappel S,Wrba F et al (2002) TP53 genotype but not p53 immunohistochemical result predictsresponse to preoperative short-term radiotherapy in rectal cancer. Some patients with symptomatic disease do nothave detectable AChR antibodies by theses assays andhave been traditionally termed seronegative myastheniagravis

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